English alias: | D-Ser；D-Serin；D-SERINE；D-Ser-OH H-D-Ser-OH；D-(+)-Serine；β-Hydroxyalanine D-2-Amino-3-Hydroxypropionic； D-2-Amino-3-hydroxypropanoic acid； (R)-2-AMINO-3-HYDROXYPROPIONIC ACID； (R)-2-amino-3-hydroxypropanoic acid； (2R)-2-amino-3-hydroxy-propanoic acid |
Introduction D-serine (D-serine) is an amino acid that, like L-serine, is converted from glutamic acid. D-serine plays an important neurotransmitter role in the central nervous system, particularly as a co-agonist of N-methyl-D-aspartate receptors (NMDAR). In the human body, D-serine is mainly synthesized by glutamate dehydrogenase and serine esterase, and is mainly found in the brain and kidney. Its concentration in the human brain is lower than that of L-serine, but its concentration in neurons and glial cells is quite high. As an agonist of NMDAR receptors, D-serine is involved in a variety of physiological processes, including memory, learning, neural development, and pain perception. In addition, D-serine is also related to the occurrence of neuropsychiatric diseases, such as schizophrenia. In general, D-serine, as an important neurotransmitter, is of great significance in neuroscience research. |
Morphology and its properties D-serine is a white crystalline powder, tasteless and odorless, easily soluble in water. It is a chiral molecule with one chiral center, and it is a stereoisomer of D-configuration, which is very similar to L-serine in chemical structure, except that their three-dimensional configuration is different. D-serine is mainly synthesized in vivo by glutamate dehydrogenase and serine esterase, and its concentration in the human brain is lower than that of L-serine, but its concentration in neurons and glial cells is quite high. As an agonist of NMDA receptors, it can regulate the excitability and inhibition of neurons, and is involved in a variety of physiological processes, including learning, memory, neurodevelopment and pain perception. D-serine is also a very stable compound that can exist stably under both acidic and alkaline conditions. In addition, it is not easy to be degraded by various enzymes, so its half-life in organisms is relatively long, which makes it have a longer acting time and a wider range of biological activities. |
China
