Basic information Safety Related Supplier

ChemicalBook Product Catalog D-I03

1/1

D-I03 NEW

$31.00 1mg

$44.00 2mg

$70.00 5mg

Min. Order
Purity99.04%
Cas No688342-78-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

show more

Chemical Properties

Product Name	D-I03
CAS No	688342-78-1
EC-No
Min. Order
Purity	99.04%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	D-I03
Description	D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. It specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 values of 5 µM and 8 µM, respectively. D-I03 also inhibits the growth of BRCA1 and BRCA2 deficient cells and prevents the formation of damage-induced RAD52 foci, but does not affect RAD51 foci induced by Cisplatin.
In vitro	D-IO3 (0-10 μM; on Days 1 and 3; Capan-1 and UWB1.289 cells) treatment preferentially inhibited the growth of Capan-1 and UWB1.289 cells in a concentration-dependent manner . D-IO3 inhibited cisplatin-induced RAD52 foci formation in the BCR-ABL1-positive BRCA1-deficient 32Dcl3 mouse hematopoietic cell line expressing GFP-RAD52. In the presence of D-IO3 (2.5 μM), the proportion of cells with RAD52 lesions decreased from 38.7% to 171%; meanwhile, the proportion of cisplatin-treated cells without lesions increased from 48.4% to 71.9%. D-IO3 had no effect on cisplatin-induced RAD51 foci. Similarly, D-I03 alone (in BRCA1-deficient cells) induced neither RAD51 nor RAD52 lesions, indicating that D-I03 has low genotoxicity[1].
In vivo	D-IO3 (50 mg / kg / day; intraperitoneal injection; daily; 7 consecutive days; nu / nu mice) treatment can reduce the growth of BRCA1-deficient MDA-MB-436 tumors. Talazoparib puls D-I03 does not cause any obvious toxicity to normal tissues and organs, and does not affect the growth of BRCA1-positive tumors. Pharmacokinetic and toxicity studies have shown that the maximum tolerated dose of D-I03 is ≥50mg / kg and t1 / 2 is 23.4 hours, resulting in a maximum concentration in peripheral blood> 1μM[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 90 mg/mL (210 mM)
Keywords	DI 03 \| DI-03 \| D-I03
Inhibitors Related	Rifampicin \| 5-Fluorouracil \| Ribavirin \| Guanidine hydrochloride \| 2,4-D \| Resveratrol \| Trimethoprim \| Azelaic acid \| Acyclovir \| Thymidine \| Temozolomide \| Folic acid
Related Compound Libraries	DNA Damage & Repair Compound Library \| Bioactive Compound Library \| Inhibitor Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book