| Name | D-Glutamic acid |
| Description | D-Glutamic acid ((R)-Glutamic acid), the enantiomer of L-glutamic acid, is widely used in medicine and food. |
| In vitro | Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu), are widely found in mammals, including humans, and are considered candidate new physiologically active substances and/or biomarkers. D-[Asp/Glu] (4 mg/mL) inhibited the binding of IgE to peanuts (75%), while D-Glu and D-Asp had no inhibitory effect. IgE is specific to D-[Asp/Glu] and may have the potential to remove IgE or reduce its binding to peanut allergens. |
| In vivo | At present, D-glutamic acid is receiving attention as a regulator of neuronal transmission and hormone secretion. It is only metabolized by D-aspartate oxidase in mammals. After intraperitoneal injection, L-glutamic acid is catabolized by α-ketoglutarate, and D-glutamic acid is converted to n-pyrrolidone carboxylic acid. The carbon 2 of D- and L-glutamic acid is converted to methyl acetate in the cecum. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 10 mg/mL (67.97 mM), Sonication is recommended.
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| Keywords | Endogenous Metabolite | Inhibitor | Glutamic acid | DGlutamic acid | D Glutamic acid | D-Glutamic acid | inhibit |
| Related Compound Libraries | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Mouse Metabolite Compound Library |
United States
