Glucosamine (hydrochloride) is a natural product.IC50 value:Target:In vitro: Glucosamine hydrochloride exhibited dose-dependent DPPH antioxidant activity [1]. Short-term (4 h) glucosamine hydrochloride treatment inhibited HIF-1α at the protein level, decreased phosphorylation of p70S6K and S6, translation-related proteins [2]. In the obstructed kidneys and TGF-β1-treated renal cells, glucosamine hydrochloride significantly decreased renal expression of α-smooth muscle actin, collagen I, and fibronectin [3]. In vivo:
[1]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.
[2]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.
[3]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.
Chemical & Physical Properties
Boiling Point
449.9ºC at 760 mmHg
Melting Point
190-194ºC
Molecular Formula
C6H14ClNO5
Molecular Weight
215.632
Flash Point
225.9ºC
Exact Mass
215.056046
PSA
124.01000
Index of Refraction
72 ° (C=1, H2O)
MSDS
D-Glucosamine hydrochloride MSDS(Chinese)
Toxicological Information
CHEMICAL IDENTIFICATION
RTECS NUMBER :
LZ6665000
CHEMICAL NAME :
D-Glucose, 2-amino-2-deoxy-, hydrochloride
CAS REGISTRY NUMBER :
66-84-2
LAST UPDATED :
199701
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H13-N-O5.Cl-H
MOLECULAR WEIGHT :
215.66
WISWESSER LINE NOTATION :
VHYZYQYQYQ1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6200 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - sensory change involving peripheral nerve
MUTATION DATA
TEST SYSTEM :
Fish - not otherwise specified
DOSE/DURATION :
1000 ppm
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 28,176,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2043 No. of Facilities: 1651 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 16143 (estimated) No. of Female Employees: 13164 (estimated)
Literature: European Journal of Pharmacology, , vol. 579, # 1-3 p. 74 - 85
Bate-D-Galactos...
CAS#:3006-60-8
~%
D-Glucosamine h...
CAS#:66-84-2
N/A
CAS#:4704-14-7
Literature: Journal of the Chemical Society, , p. 81,85
Precursor & DownStream
Precursor 2
CAS#:9012-76-4 Chitosan
CAS#:3006-60-8 Bate-D-Galactos...
DownStream 10
Previous 1/3 Next
CAS#:3068-34-6 2-acetamido-2-d...
CAS#:3416-24-8 Glucosamine
CAS#:41107-82-8 2,5-anhydromannitol
CAS#:123-76-2 Levulinic acid
Customs
HS Code
2922399090
Summary
2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles20
More Articles
The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation.
FEBS J. 281(16) , 3591-608, (2014)
Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glu...
Qualitative and quantitative determination of peptides related to celiac disease in mixtures derived from different methods of simulated gastrointestinal digestion of wheat products.
Anal. Bioanal. Chem 406(19) , 4765-75, (2014)
During wheat digestion, gluten-derived proteolytic resistant peptides are generated, some of them involved in celiac disease. In vitro digestion models able to mimic the peptides generated in the huma...
The dissolution enhancement of piroxicam in its physical mixtures and solid dispersion formulations using gluconolactone and glucosamine hydrochloride as potential carriers.
Pharm. Dev. Technol. 20(1) , 74-83, (2015)
The solid dispersion technique is one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however this is reliant on a suitable carrier and solvent being se...
Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.