| Name | Cyproterone acetate |
| Description | Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels.Cyproterone binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. Cyproterone Acetate is the acetate salt of a synthetic steroidal antiandrogen with weak progestational and antineoplastic activities. This agent also exerts progestational agonist properties at the level of the pituitary that reduce luteinizing hormone (LH), resulting in reductions in testicular androgen secretion and serum testosterone levels. Treatment with cyproterone alone results in incomplete suppression of serum testosterone levels. |
| In vitro | Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages |
| In vivo | Cyproterone acetate inhibited T-stimulated 3XHRE-LUC transcription at low concentrations in the presence of testosterone (10 nM), but not at high concentrations.Cyproterone acetate has both pronounced antagonistic and partial activator properties, and activates the AR at high relative concentrations (EC50 of 4.0 μM). In J774 macrophages |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 10 mg/mL (23.98 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 40 mg/mL (95.94 mM), Sonication is recommended.
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| Keywords | Androgen Receptor | Cyproterone | DR5 | hormonal | cancer | inhibit | tumorigenesis | prostate | cells | Cyproterone acetate | steroid | Inhibitor | Cyproterone Acetate |
| Inhibitors Related | Dehydroisoandrosterone 3-acetate | S-23 | Allura Red AC | Sunset Yellow FCF | Flutamide |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
United States
