| Name | Cyclic-di-GMP disodium |
| Description | Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer. |
| In vitro | METHODS: H508 cells were treated with cyclized-di-GMP disodium (5GP-5GP disodium) (0.5-50 μM, 5 days) and cell proliferation was measured using a validated sulforhodamine B (SRB) colorimetric assay.
RESULTS The highest concentration (50 μM) of c-di-GMP reduced H508 cell proliferation by approximately 15%. [1]
METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (50, 100μM) was used to treat Jur kat cells, and the CD4 level in the cells was observed.
RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 50μM can induce a 6.3-fold increase in CD4 levels in Jur kat cells, and this was dose-dependent. Cyclic-di-GMP disodium (5GP-5GP disodium) at a concentration of 100μM treated Jur kat cells, resulting in a 9.1-fold increase in CD4 compared to the control group. [2] |
| In vivo | METHODS: Cyclic-di-GMP disodium (5GP-5GP disodium) (100 μg, intravenous injection) was used in mice in the primary and booster phases to verify whether it would further enhance the immune response to TriVax.
RESULTS Cyclic-di-GMP disodium (5GP-5GP disodium) can effectively enhance the magnitude of the immune response produced by TriVax. [3] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 144.0 mg/mL (196.1 mM), Sonication is recommended.
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| Keywords | STING | EndogenousMetabolite | Endogenous Metabolite | Cyclic-di-GMP disodium | Cyclic di-GMP | CD4 |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
United States
