1. Product information
Names
| Name | N-Boc-trans-4-Hydroxy-L-proline methyl ester |
|---|
| Synonym | More Synonyms |
|---|
Boc-Hyp-OMe Biological Activity
| Description | Boc-Hyp-OMe
is a non-cleavable ADC linker used in the synthesis of antibody-drug
conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC
linker that can be used in the synthesis of PROTACs[1][2]. |
|---|
| Related Catalog | Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs
are comprised of an antibody to which is attached an ADC cytotoxin
through an ADC linker[1]. PROTACs contain two different ligands
connected by a linker; one is a ligand for an E3 ubiquitin ligase and
the other is for the target protein. PROTACs exploit the intracellular
ubiquitin-proteasome system to selectively degrade target proteins[2]. |
|---|
| References | [1]. Beck
A, et al. Strategies and challenges for the next generation of
antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 335.2±42.0 °C at 760 mmHg |
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| Melting Point | 92-96 °C(lit.) |
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| Molecular Formula | C11H19NO5 |
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| Molecular Weight | 245.272 |
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| Flash Point | 156.6±27.9 °C |
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| Exact Mass | 245.126328 |
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| PSA | 76.07000 |
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| LogP | -0.25 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.501 |
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| Storage condition | 2~8°C |
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MSDS
Boc-Hyp-OMe MSDS(Chinese) |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2933990090 |
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Precursor & DownStream
| Precursor 9 | Previous 1/3 Next |
|---|
 CAS#:24424-99-5
Di-tert-butyl d...
 CAS#:40216-83-9
H-Hyp-OMe hydro...
 CAS#:13726-69-7
Boc-Hyp-OH
 CAS#:74-88-4
methyl iodide
|
| DownStream 10 | Previous 1/3 Next |
|---|
 CAS#:336818-78-1
(2S,4R)-Boc-4-P...
 CAS#:487048-28-2
n-boc-cis-4-cya...
 CAS#:317357-42-9
3-FLUORO-4-FORM...
 CAS#:51-35-4
L-Hydroxyproline
|
Customs
| HS Code | 2933990090 |
|---|
| Summary | 2933990090.
heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%.
Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester |
| N-BOC-transydro-L-prolinemethylester |
| 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate |
| N-BOC-4-HYDROXY-L-PROLINE METHYL ESTER |
| N-BOC-L-Hydroxyproline methyl ester |
| 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate |
| BOC-HYDROXYPROLINE-OME |
| N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester |
| BOC-L-4-HYDROXYPROLINE METHYL ESTER |
| N-Boc-trans-hydro-L-prolinemethylester |
| N-Boc-cis-4-Hydroxy-L-prolinem ethylester |
| N-Boc-trans-4-Hydroxy-L-prolinemethylester |
| Boc-Hyp-Ome |
| (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate |
| MFCD00076981 |
| BOC-L-HYDROXYPROLINE METHYL ESTER |
| BOC-L-T-4-HYDROXYPROLINE METHYL ESTER |
| Boc-trans-4-hydroxy-L-proline methyl ester |
| N-Boc-cis-4-hydroxy-L-proline methyl ester |
| Boc-cis-Hyp-OMe |
| cis-Boc-Hyp-OMe |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
Email address : Sun@fdachem.com
Mob: 86 13526505137
WhatsApp/Skype/Wechat/LINE: 86 13526505137
China
