Synthetic creatine can be used as a nutritional supplement to promote skeletal muscle to adapt to vigorous exercise and fight against weak individuals; It can also be used to prepare drugs with respiratory insufficiency; Preparation of pharmaceutical preparations containing human growth hormone; It can also be used to compound a new healthy food and restore the effectiveness of youth. Because creatine is not a hormone, it does not cause any interference and damage to the human body, and will not cause drug-dependent or physiological side effects, so creatine supplements have become popular in recent years. Creatine exists in fish and meat products, but its quantity is very small. It is difficult to obtain all of it from food to reach the daily intake of each person that is helpful for muscle growth. A large number of studies have reported that supplementation of creatine monohydrate can increase the content of creatine in skeletal muscle. Creatine can be converted into creatine phosphate under the action of creatine kinase, thus increasing the metabolism pool of creatine phosphate. The change of creatine metabolism caused by supplementation with creatine monohydrate may change the original meat quality status of the body. Although there are few reports on the application of creatine in livestock and poultry production at present, and the results are quite different, it provides a new and effective way to improve the quality of livestock and poultry meat, and shows great application potential.