| Name | CP-809101 hydrochloride |
| Description | CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 values of 9.96 for human 5-HT2C, 7.19 for 5-HT2B, and 6.81 for 5-HT2A receptors. |
| In vitro | CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro[4]. |
| In vivo | Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 20 mg/mL (58.61 mM), Sonication is recommended.
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| Keywords | Serotonin Receptor | nicotine dependence | nicotine | Inhibitor | inhibit | hyperactivity | CP-809101 Hydrochloride | CP809101 Hydrochloride | CP809101 hydrochloride | CP-809101 | CP809101 | CP 809101 Hydrochloride | CP 809101 hydrochloride | CP 809101 | conditioned avoidance responding | antipsychotic | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT2C | 5-HT2B | 5-HT2A | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | pCPA methyl ester hydrochloride | 1,8-Cineole | Venlafaxine hydrochloride | Tryptamine hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Neurotransmitter Receptor Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Serotonin Receptor-Targeted Compound Library |
United States
