| Name | COX-2-IN-6 |
| Description | COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer. |
| In vitro | COX-2-IN-6 (Compound 10) inhibits human COX-2/COX-1 enzyme and COX-2/COX-1-driven PGE2 synthesis in HEK293 cells, with IC50 of 0.84 μM、>50 μM、0.60 μM and, >50 μM, respectively.[1]
COX-2-IN-6 exhibits stability in human or mouse liver microsomes and hepatocytes in vitro. The T1/2 value of human hepatocytes is 3.1 min, and the T1/2 value of mouse hepatocytes is 3.0 min.[1] |
| In vivo | COX-2-IN-6 (Compound 10) (30, 100, 300 mg/kg; oral; single dose; APCmin/mouse model) inhibits adenoma progression and extends survival in the APCmin/+ mouse model.[1]
COX-2-IN-6 (10 mg/kg; oral; single dose; APCmin/+ mouse model) exhibits high colonic exposure (>4300 ng/g) and low systemic exposure (<6 ng/mL), C/P distribution ratio > 1200 in 4 hours.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (146.52 mM), Sonication is recommended.
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| Keywords | ProstaglandinReceptor | Prostaglandin Receptor | PGE2 | COX-2 |
| Inhibitors Related | Ibuprofen | Acetaminophen | Salicylamide | Salicin | Diclofenac sodium | Diclofenac Potassium | Meloxicam | Paradol | Indomethacin sodium hydrate | Salicylic acid | Glafenine | Revaprazan hydrochloride |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library |
United States
