| Name | Concanamycin A |
| Description | Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection. |
| In vitro | In CD8+ cytotoxic T lymphocytes (CTLs), Concanamycin A (100 nM; 0, 4, 8, 12, 16, 20 hours) induced rapid cell death instead of apoptosis at 20 hours, without observed nuclear condensation[2]. |
| In vivo | In wild type mice, Concanamycin A (15 mg/kg; intravenous injection at 0, 10, or 24 hours prior to sacrifice) resulted in significant liver injury, as demonstrated by increased serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and elevated expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 and 24 hours following administration[5]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 8 mg/mL (9.24 mM), Sonication is recommended.
Methanol : 8 mg/mL (9.24 mM), Sonication and heating are recommended.
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| Keywords | Vacuolar type H+-ATPase | HIVProtease | HIV Protease | HIV | Folimycin | Concanamycin A |
| Inhibitors Related | Neomycin sulfate | Emtricitabine | Adipic dihydrazide | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Metronidazole | Lamivudine | Copper(Ⅱ) Sulfate | Doxycycline | Dextran sulfate sodium salt (MW 5000) | BES |
United States
