Pharmacodynamics Colistin is a polypeptide antibacterial drug, is a kind of alkaline cationic surfactant, through the fine with bacteria The phospholipids in the cell membrane interact, penetrate into the bacterial cell membrane, destroy its structure, and then cause changes in membrane permeability, resulting in bacteria Death, produce bactericidal effect. This product against aerobic bacteria, Escherichia coli, Haemophilus, Klebsiella, Pasteurella, Pseudomonas aeruginosa, Salmonella Gram-negative bacteria such as Shigella have strong antibacterial effect. Gram-positive bacteria are usually insensitive. There is a complete relationship with polycolistin B Total cross-resistance, but no cross-resistance with other antibiotics. pharmacokinetics Oral administration is almost non-absorbable, but non-gastrointestinal administration absorbs rapidly. Drugs that enter the body can be distributed quickly Heart, lung, liver, kidney and skeletal muscle, but not easy to enter the brain spinal cord, chest, joint cavity and infection lesions. It is mainly excreted through the kidney.
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China
