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ChemicalBook Product Catalog COH-SR4

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COH-SR4 NEW

$ 37.00 /50mg

Min. Order
Purity98.96%
Cas No73439-19-7
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	COH-SR4
CAS No	73439-19-7
EC-No
Min. Order
Purity	98.96%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	COH-SR4
Description	COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation. COH-SR4 modulates amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cells
In vivo	SR4 is a novel mitochondrial uncoupler with anti-obesity and anti-diabetic properties.?SR4 increased oxygen consumption, dissipated mitochondrial membrane potential, induced mitochondrial swelling, and decreased intracellular ATP in cultured cells and isolated liver mitochondria.?Oral feeding of SR4 significantly reduced body weight gain, improved glycemic control and insulin resistance, and prevented dyslipidemia in both high-fat-diet (HFD) induced obese and diabetic db/db mice.?SR4 treatment also decreased liver triglycerides and prevented hepatic steatosis in both animal models.?Mitochondrial uncoupling of SR4 results to activation of AMP-activated protein kinase (AMPK), leading to the phosphorylation and inhibition of acetyl-CoA carboxylase (ACC).?Gene analyses by RT-PCR showed SR4 significantly suppressed the mRNA expression of several lipogenic genes and gluconeogenic genes in the liver of HFD obese mice.?RNA sequencing analysis showed that 642 genes were differentially expressed in liver of db/db mice after SR4 treatment (217 upregulated, 425 down-regulated).?Gene ontology analysis by DAVID indicated SR4 upregulated amino acid metabolism and down-regulated lipid and fatty acid synthesis and glucose metabolism.?These studies demonstrate that SR4 may be a promising compound for treatment of T2DM and obesity
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 4 mg/mL (11.43 mM)
Keywords	anticancer \| anti-proliferative \| kinase \| leukemia \| protein \| breast \| cancers \| lung \| COH SR4 \| COH-SR4 \| COHSR4 \| anti-adipogenic \| COH-SR-4 \| Inhibitor \| AMPK \| melanoma \| inhibit \| AMP-activated protein kinase \| Mitochondria uncoupler SR4 \| AMP-activated
Inhibitors Related	Phenformin hydrochloride \| AICAR \| Doxorubicin hydrochloride \| Adenosine monophosphate \| Metformin \| Methyl cinnamate \| A-769662 \| Metformin hydrochloride \| Chitosan oligosaccharide \| Buformin hydrochloride \| HTH-01-015 \| AMPK activator 4
Related Compound Libraries	Glycometabolism Compound Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Inhibitor Library \| Neuroprotective Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-Metabolism Disease Compound Library \| Anti-Cancer Active Compound Library \| Neuronal Differentiation Compound Library

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