CMS121
Modify Date: 2024-01-02 20:42:47
 CMS121 structure | Common Name | CMS121 |
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| CAS Number | 1353224-53-9 | Molecular Weight | 321.37 |
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| Density | N/A | Boiling Point | N/A |
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| Molecular Formula | C20H19NO3 | Melting Point | N/A |
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| MSDS | N/A | Flash Point | N/A |
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Use of CMS121
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3]. |
CMS121 Biological Activity
| Description | CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3]. |
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| Related Catalog | Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Acetyl-CoA Carboxylase Research Areas >> Neurological Disease |
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| Target | Acetyl-CoA carboxylase 1 (ACC1)[1] |
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| In Vitro | CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1] Cell Line: HT22 cells Concentration: 1 µM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79. |
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| In Vivo | CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1]. Animal Model: Female SAMP8 mice (9 months old)[1] Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
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| References | [1]. Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. [2]. Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. [3]. Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. |
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Chemical & Physical Properties
| Molecular Formula | C20H19NO3 |
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| Molecular Weight | 321.37 |
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| Storage condition | -20°C |
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Company Profile
Our company is a high-tech enterprise specializing in chemical raw materials such as electronic materials, optoelectronic materials, semiconductor materials, UV monomers, silane catalysts, cosmetic raw materials, etc. The company integrates research and development, production, customized synthesis, and sales, and is committed to providing customers with high-quality chemical product solutions.
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