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ChemicalBook Product Catalog CLOZAPINE N-OXIDE

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CLOZAPINE N-OXIDE NEW

$30.00 2mg

$45.00 5mg

$76.00 10mg

Min. Order
Purity99.94%
Cas No34233-69-7
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	CLOZAPINE N-OXIDE
CAS No	34233-69-7
EC-No
Min. Order
Purity	99.94%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	CLOZAPINE N-OXIDE
Description	Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
In vitro	METHODS: hM4Di-transduced primary embryonic rat neuronal cultures were treated with Clozapine N-oxide (0.01-1000 nM), and activity on hM4Di receptors was detected by FLIPR assay. RESULTS: The EC50 value for Clozapine N-oxide was 8.1 nM. [1] METHODS: WT and hM3Dq-transfected mouse embryoma cells ATDC5 were treated with Clozapine N-oxide (750 nM) to detect intracellular calcium signaling. RESULTS: Administration of Clozapine N-oxide resulted in immediate coordinated induction of single [Ca2+]i spines in hM3Dq-ATDC5 cells, and only spontaneous [Ca2+]i signaling was observed in Clozapine N-oxide-treated WT controls. [2]
In vivo	METHODS: To investigate potential effects on sleep, Clozapine N-oxide (1-10 mg/kg) was injected intraperitoneally into C57BL/6J mice. RESULTS: Clozapine N-oxide altered sleep in mice. Sleep was analyzed using electroencephalography (EEG) and electromyography (EMG), revealing dose-dependent suppression of rapid eye movement (REM) sleep, changes in EEG spectral power during non-rapid eye movement (NREM) sleep, and alterations in sleep structure. [3] METHODS: To investigate the effects on reward-seeking behavior, Clozapine N-oxide (0.1-10 mg/kg) was administered intraperitoneally to C57BL6/JJcl mice. RESULTS: The off-target effects of commonly used doses of Clozapine N-oxide on motivated reward seeking were negligible. [4]
Storage	Powder: -20°C for 3 years \| Shipping with blue ice.
Solubility Information	Saline : 25 mg/mL (72.92 mM) H2O : 1 mg/mL (2.92 mM), Sonication is recommended. Ethanol : 10 mg/mL DMSO : 60 mg/mL (175.02 mM), The compound is unstable in solution, please use soon.
Keywords	Clozapine N-oxide \| Dopamine Receptor \| BBB \| Drug Metabolite \| hM3Dq \| metabolite \| inhibit \| Clozapine \| G-protein \| Muscarinic acetylcholine receptor \| mAChR \| muscarinic-M4 \| CLOZAPINE NOXIDE \| CLOZAPINE N-OXIDE \| CLOZAPINE N OXIDE \| Inhibitor \| DREADDs
Inhibitors Related	Adiphenine hydrochloride \| Alverine citrate \| Dapoxetine hydrochloride \| Mycophenolate Mofetil \| Ribavirin \| Octopamine hydrochloride \| Adenine \| Isonicotinic acid \| Choline chloride \| Propoxur

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