ChemicalBook Product Catalog clonixin

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clonixin NEW

$2.00 100kg

$4.00 10kg

$6.00 1kg

Min. Order1kg
Purity99%
Cas No17737-65-4
Supply Ability100kg
Update time2025-08-05

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

VIP1Y

China

Chemical Properties

Product Name	clonixin
CAS No	17737-65-4
EC-No
Min. Order	1kg
Purity	99%
Supply Ability	100kg
Release date	2025/08/05

PRODUCT INFORMATION

Common Name	clonixin
CAS Number	17737-65-4	Molecular Weight	262.692
Density	1.4±0.1 g/cm3	Boiling Point	410.2±45.0 °C at 760 mmHg
Molecular Formula	C13H11ClN2O2	Melting Point	242 °C
MSDS	ChineseUSA	Flash Point	201.9±28.7 °C
Symbol	GHS07	Signal Word	Warning

Purity		Quantity		Budget		Inquiry

Use of clonixin

Clonixin (SCH-10304) is an orally active analgesic and a non-steroidal anti-inflammatory agent in rodents[1].

Properties
Articles29
Spectrum

Name	clonixin
Synonym	More Synonyms

Description	Clonixin (SCH-10304) is an orally active analgesic and a non-steroidal anti-inflammatory agent in rodents[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. V B Ciofalo, et al. Anti-nociceptive Activity of Clonixin in Rhesus Monkeys. Jpn J Pharmacol. 1972 Dec;22(6):749-53. [2]. J S Finch, et al. Clonixin: A Clinical Evaluation of a New Oral Analgesic. J Clin Pharmacol New Drugs. Sep-Oct 1971;11(5):371-7.

Description

Clonixin (SCH-10304) is an orally active analgesic and a non-steroidal anti-inflammatory agent in rodents[1].

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

References

[1]. V B Ciofalo, et al. Anti-nociceptive Activity of Clonixin in Rhesus Monkeys. Jpn J Pharmacol. 1972 Dec;22(6):749-53.

[2]. J S Finch, et al. Clonixin: A Clinical Evaluation of a New Oral Analgesic. J Clin Pharmacol New Drugs. Sep-Oct 1971;11(5):371-7.

Density	1.4±0.1 g/cm3
Boiling Point	410.2±45.0 °C at 760 mmHg
Melting Point	242 °C
Molecular Formula	C13H11ClN2O2
Molecular Weight	262.692
Flash Point	201.9±28.7 °C
Exact Mass	262.050903
PSA	62.22000
LogP	5.09
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.665
Storage condition	room temp

clonixin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QT0960000

CHEMICAL NAME :
Nicotinic acid, 2-(3-chloro-o-toluidino)-

CAS REGISTRY NUMBER :
17737-65-4

BEILSTEIN REFERENCE NO. :
0483212

LAST UPDATED :
199612

DATA ITEMS CITED :
11

MOLECULAR FORMULA :
C13-H11-Cl-N2-O2

MOLECULAR WEIGHT :
262.71

WISWESSER LINE NOTATION :
T6NTJ BMR CG B1& CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
335 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
148 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
325 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
400 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
198 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
263 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
2240 mg/kg/4W-C

TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Blood - normocytic anemia

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
10920 mg/kg/26W-C

TOXIC EFFECTS :
Gastrointestinal - ulceration or bleeding from stomach Endocrine - changes in spleen weight Blood - normocytic anemia

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
2240 mg/kg

SEX/DURATION :
male 28 day(s) pre-mating

TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
280 mg/kg

SEX/DURATION :
female 9-15 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,453,1975

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
560 mg/kg

SEX/DURATION :
female 7-13 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,453,1975

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
HS Code	2933399090

Precursor 2
CAS#:2942-59-8 2-Chloronicotin... CAS#:87-60-5 3-Chloro-2-meth...
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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