PRODUCT NAME:CIMETIDINE
CAS NO.:51481-61-9
EINECS: 257-232-2
MOLECULAR WEIGHT: 252.33924
FORMULA: C10H16N6S
DENSITY:1.27
BOILING POINT:488°CAT760MMHG
MELTING POINT:139-144ºC
FLASH POINT:248.9°C
STORAGE TEMPERATURE:2-8°C
REFRACTIVE INDEX:1.5700 (ESTIMATE)
APPEARANCE:WHITE POWDER
PURITY: ≥98%
COUNTRY OF ORIGIN:CHINA
Function
Some evidence suggests cimetidine could be effective in the treatment of common warts, but more rigorous double-blind clinical trials found it to be no more effective than a placebo.
Another study used cimetidine for the treatment of chronic calcific tendinitis of the shoulder.The small-scale study took 16 individuals with calcific tendinitis in one shoulder, all of which had previously attempted other forms of therapy, including steroid injection and arthroscopic lavage. During the course of the study, 10 patients reported an elimination of pain and nine displayed a complete disappearance of calcium deposits. With results being on a small scale, cimetidine, for the treatment of chronic calcific tendinitis of the shoulder, has been recommended to be opened to large-scale clinical trials.
Tentative evidence supports a beneficial role as add-on therapy in colorectal cancer.
Application
Reported side effects of cimetidine include diarrhea, rashes, dizziness, fatigue, constipation, and muscle pain, all of which are usually mild and transient.It has been reported that mental confusion may occur in the elderly.Because of its hormonal effects, cimetidine rarely may cause sexual dysfunction including loss of libido and erectile dysfunction and gynecomastia (0.1-0.2%) in males during long-term treatment.Rarely, interstitial nephritis, urticaria, and angioedema have been reported with cimetidine treatment.Cimetidine is also commonly associated with transient raised aminotransferase activity; hepatotoxicity is rare.
China
