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ChemicalBook Product Catalog cim0216

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cim0216 NEW

$39.00 1mg

$54.00 2mg

$84.00 5mg

Min. Order
Purity99.87%
Cas No1031496-06-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	cim0216
CAS No	1031496-06-6
EC-No
Min. Order
Purity	99.87%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	cim0216
Description	CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.
In vitro	CIM0216 Selectively Activates TRPM3 in Stably Transfected HEK293 Cells.A diverse small-molecule library was screened for compounds that modulate TRPM3-mediated Ca2+ responses in HEK293 cells stably expressing murine TRPM3 (HEK-TRPM3 cells), as described previously[1].In HEK-TRPM3 cells, CIM0216 elicited a dose-dependent Ca2+ response [negative logarithm of the EC50 value (pEC50) = 0.77 ± 0.1 μM], which was not observed in nontransfected HEK293 cells . The endogenous TRPM3 activator pregnenolone sulfate (PS) also elicited a dose-dependent Ca2+ response, typified by a smaller Ca2+ influx and a fivefold lower potency (pEC50 = 3.0 ± 0.1 μM; n = 2) compared with CIM0216 . In the presence of 40 μM PS, the dose dependency of CIM0216 shifted to a lower concentration in HEK-TRPM3 cells (pEC50 = 42 ± 0.6 nM CIM0216 in the presence of PS). Single-cell FURA2-ratiometric Ca2+ imaging revealed a robust increase in intracellular Ca2+ concentration (1,145 ± 26 nM; n = 603 from at least three independent measurements) on stimulation with 1 μM CIM0216 in all HEK-TRPM3 cells. These responses were not observed in nontransfected HEK cells (n = 166) or in the absence of extracellular Ca2+.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 65 mg/mL (187.1 mM), Sonication is recommended. Ethanol : 17 mg/mL (48.93 mM), Sonication and heating are recommended.
Keywords	cim-0216 \| inflammation \| inhibit \| TRP Channel \| cim0216 \| Transient receptor potential channels \| sensory nerve \| neurogenic \| TRPM3 \| Inhibitor \| CIM 0216
Inhibitors Related	(+)-Camphor \| AP 18 \| Methyl syringate \| Caffeic Acid \| Oleoyl Serotonin \| (-)-Menthol \| Camphor \| Pregnenolone \| Probenecid \| 1,4-Cineole \| Methyl salicylate \| SKF-96365 hydrochloride
Related Compound Libraries	Bioactive Compound Library \| Pain-Related Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Ion Channel Targeted Library \| Anti-Cancer Compound Library

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