| Name | Ciliobrevin D |
| Description | Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity in vitro. |
| In vitro | Ciliobrevin D reversibly inhibits melanosome aggregation, however, the non-cilia-disrupting derivative had no discernible effect at comparable doses. Cells treated with Ciliobrevin D exhibits abnormal (unfocused, multipolar, or collapsed) spindles with disrupted γ-tubulin localization in NIH-3T3 cells. Ciliobrevin D addition also reversibly disrupts the pre-formed spindles of metaphase-arrested cells and reduces overall microtubule levels and it similarly abrogates the movement of peroxisomes in Drosophila S2 cells[1]. |
| In vivo | In the testis in vivo, Knockdown of Dync1h1 or inactivation of dynein 1 by Ciliobrevin D perturbs spermatogenesis. The use of Ciliobrevin D to inactivate dynein 1 in the testis in vivo perturbs MT organization through changes in the spatial expression of EB1, perturbs F-actin organization, and perturbs distribution of adhesion protein complexes at the BTB, leading to a loss of BTB integrity[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 5 mg/mL (12.73 mM), Sonication and heating to 80℃ are recommended.
|
| Keywords | inhibit | melanosome | spindles | cytoplasmic | Ciliobrevin D | γ-tubulin | Inhibitor | dynein | ATPases | Hedgehog | peroxisomes | aggregation |
| Inhibitors Related | Itraconazole | Naftifine hydrochloride | Tirofiban hydrochloride monohydrate | Sodium oleate | Vismodegib | trans-Aconitic acid | Phlorizin | Chlorpropamide | Revaprazan hydrochloride | Oleic acid | Esomeprazole Sodium | Trichlormethiazide |
| Related Compound Libraries | 经典已知活性库 | 膜蛋白靶向化合物库 | 微管靶向化合物库 | 抑制剂库 | 抗前列腺癌化合物库 | 线粒体靶向库 | 已知活性化合物库 | 离子通道库 | GPCR靶点分子库 | Wnt/Hedgehog/Notch 通路化合物库 |
United States
