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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Cytoskeletal Signaling Integrin inhibitors Cilengitide

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Cilengitide NEW

$61.00 2mg

$92.00 5mg

$155.00 10mg

Min. Order
Purity99.36%
Cas No188968-51-6
Supply Ability10g
Update time2026-03-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	Cilengitide
CAS No	188968-51-6
EC-No
Min. Order
Purity	99.36%
Supply Ability	10g
Release date	2026/03/13

Product Introduction

Bioactivity

Name	Cilengitide
Description	Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays) with approximately 10-fold selectivity against gpIIbIIIa.
Cell Research	Cilengitide is supplied as an apyrogenic sterile infusion solution in physiological saline. Cilengitide is diluted in saline to a concentration of 1 mM[2]. The cytotoxicity of the two drugs, Belotecan and Cilengitide, is measured by the Cell Counting Kit-8 (CCK-8). U87 mg and U251 mg cells are seeded in 96 well plates at a density of 4×103 cells per well to allow for adhesion overnight. After this, the cells are treated with Cilengitide at a concentration of 0, 0.1, 0.5, 1, 5 and 25 μM and Belotecan at a concentration of 0, 6.25, 12.5, 25, 50 and 100 nM. All possible combinations of concentrations are used to assess the combined therapeutic effect of Cilengitide and Belotecan. After 3 days, 10 μL of the CCK-8 solution is added to each well of the plate, and the plate is incubated for 3 hr in the incubator (37°C; 5% CO2). The optical density (OD) of the sample plate is measured at 450 nm in a microplate reader. The viability of tumor cells is assessed by calculating the OD ratio of the specific OD in each sample to that of the control. Each experiment is conducted in quadruplicate. The values are averaged and normalized against the controls to generate dose-response curves[2].
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	H2O : 7.69 mg/mL (13.06 mM), Sonication is recommended. DMSO : 45.45 mg/mL (77.21 mM), Sonication is recommended.
Keywords	ανβ5 \| ανβ3 \| αVβ5 integrin \| αVβ3 integrin \| Vitronectin \| integrins \| Integrin \| Inhibitor \| inhibit \| EMD-121974 \| EMD121974 \| Cilengitide \| Autophagy
Inhibitors Related	Stavudine \| Aceglutamide \| Hemin \| Tamoxifen \| Urea \| Guanidine hydrochloride \| Hydroxychloroquine \| Metronidazole \| Formamide \| Paeonol \| Naringin \| Alginic acid
Related Compound Libraries	Failed Clinical Trials Compound Library \| Bioactive Compound Library \| Cyclic Peptide Library \| Membrane Protein-targeted Compound Library \| Anti-Cancer Clinical Compound Library \| Peptide Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library \| Anti-Cancer Active Compound Library

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