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ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards Ciclesonide

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Ciclesonide NEW

$44.00 10mg

$79.00 25mg

$129.00 50mg

Min. Order
Purity99.94%
Cas No126544-47-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Ciclesonide
CAS No	126544-47-6
EC-No
Min. Order
Purity	99.94%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Ciclesonide
Description	Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases.
Cell Research	Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference)
In vitro	Ciclesonide is effectively taken up into human alveolar type II epithelial (A549) cells and metabolized to its pharmacologically active metabolite des-CIC and fatty acid conjugates of desCIC[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 54.1 mg/mL (100 mM) DMSO : 54.1 mg/mL (100 mM)
Keywords	Inhibitor \| RPR 251526 \| Ciclesonide \| RPR-251526 \| inhibit \| Glucocorticoid Receptor
Inhibitors Related	Nimodipine \| Hydrocortisone \| Mifepristone \| Prednisolone acetate \| Cortisone \| Dexamethasone acetate \| Prednisolone \| Dexamethasone \| Dexamethasone Phosphate disodium \| Prednisone acetate \| Desonide \| Corticosterone
Related Compound Libraries	Bioactive Compound Library \| Pediatric Drug Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| FDA-Approved Drug Library \| Anti-Cancer Approved Drug Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Anti-COVID-19 Compound Library \| Anti-Cancer Drug Library

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Company Profile Introduction

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