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Product Details
| Common Name | Cialis |
|---|
| CAS Number | 171596-29-5 | Molecular Weight | 389.404 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 679.1±55.0 °C at 760 mmHg |
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| Molecular Formula | C22H19N3O4 | Melting Point | 298-300ºC |
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| MSDS | N/A | Flash Point | 364.5±31.5 °C |
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| Symbol |  
GHS02, GHS07 | Signal Word | Danger |
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Use of Cialis
Tadalafil is a PDE5 inhibitor with an IC50 value of 1.8 nM.IC50 Value: 1.8±0.4nM [1]Target: PDE 5Tadalafil is marketed in pill form for treating erectile dysfunction(ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension. Tadalafil can elevate the level of cGMP in the corpus cavernosum and effectively improve ED of various causes and degrees.in vitro: Biochemical potencies (affinities) of these compounds for PDE5 determined by IC(50), K(D) (isotherm), K(D) (dissociation rate), and K(D) ((1/2) EC(50)), respectively, were the following: sildenafil (3.7 +/- 1.4, 4.8 +/- 0.80, 3.7 +/- 0.29, and 11.7 +/- 0.70 nM), tadalafil (1.8 +/- 0.40, 2.4 +/- 0.60, 1.9 +/- 0.37, and 2.7 +/- 0.25 nM); and vardenafil (0.091 +/- 0.031, 0.38 +/- 0.07, 0.27 +/- 0.01, and 0.42 +/- 0.10 nM). Thus, absolute potency values were similar for each inhibitor, and relative potencies were vardenafil >> tadalafil > sildenafil [1]. 0.5 ml tadalafil solutions with different concentrations were added (0.2, 0.1, 0.05 and 0.025 μg ml-1, respectively) into semen samples. In both groups, samples treated with 0.2 μg ml-1 tadalafil had significant increase in sperm motility after 2 h incubation [2].in vivo: The Tadalafil-treated group showed enhanced erectile function (intracavernosal pressure/mean arterial pressure) at 0.3, 0.5, 1, 3, and 5 Hz compared with diabetic group values at the respective frequencies (P <.05) that approached control values [3]. oral administration of tadalafil (20 mg) or sildenafil (100 mg) was given. In both groups, computer-assisted semen analysis parameters showed no significant difference. After the administration of tadalafil (2 h) and sildenafil (1 h), there was no significant difference observed in premature acrosome reaction incidence rate [2].Clinical trial: Study the Safety and Effectiveness of Tadalafil in Men With Problems Getting or Maintaining an Erection When Taken Prior to Desiring an Erection
| Density | 1.5±0.1 g/cm3 |
|---|
| Boiling Point | 679.1±55.0 °C at 760 mmHg |
|---|
| Melting Point | 298-300ºC |
|---|
| Molecular Formula | C22H19N3O4 |
|---|
| Molecular Weight | 389.404 |
|---|
| Flash Point | 364.5±31.5 °C |
|---|
| Exact Mass | 389.137543 |
|---|
| PSA | 74.87000 |
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| LogP | 1.43 |
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| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
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| Index of Refraction | 1.758 |
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| Storage condition | Hygroscopic, -20?C Freezer, Under Inert Atmosphere |
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Synonyms
| IC-351 |
| TADALAFIL |
| MFCD07771966 |
| (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a tetrahydropyrazino [1',2':1,6] pyrido[3,4b] indole1,4(6H,7H)-dione |
| Tadalafei |
| Cialis |
| Tildenafil |
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