Chlorhexidine NEW

• DATA ITEMS CITED :

• 16

• MOLECULAR FORMULA :

• C22-H30-Cl2-N10

• MOLECULAR WEIGHT :

• 505.52

• WISWESSER LINE NOTATION :

• GR DMYUM&MYUM&M6MYUM&MYUM&MR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Human

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 9200 uL/kg

• TOXIC EFFECTS :

• Behavioral - ataxia Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 60 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• >1 gm/kg

• TOXIC EFFECTS :

• Gastrointestinal - changes in structure or function of salivary glands

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 21 mg/kg

• TOXIC EFFECTS :

• Behavioral - convulsions or effect on seizure threshold

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 2515 mg/kg

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - acute pulmonary edema

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 44 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 632 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 24 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD - Lethal dose

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• >8 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 150 uL/kg/30D-I

• TOXIC EFFECTS :

• Blood - changes in leukocyte (WBC) count Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 1680 mg/kg

• SEX/DURATION :

• female 7 day(s) pre-mating

• TOXIC EFFECTS :

• Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

• TYPE OF TEST :

• DNA repair

• TEST SYSTEM :

• Bacteria - Escherichia coli

• DOSE/DURATION :

• 7 umol/disc

• REFERENCE :

• CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 28,249,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84812 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 32 (estimated) No. of Female Employees: 32 (estimated)