| Name | Chlorhexidine digluconate |
| Description | Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant with broad-spectrum antimicrobial activity, inhibits both Gram-positive and Gram-negative bacteria, induces necrosis and apoptosis, and can be used in the study of bacterial infections. |
| In vitro | Chlorhexidine digluconate exhibits dose-dependent and time-dependent effects on Chinese hamster ovary (CHO) cells (P < 0.05). As the concentration of Chlorhexidine digluconate increases, the mode of cell death shifts from apoptosis to necrosis: Chlorhexidine digluconate (0.00005%, 0.0001%, 0.0005%; 1 hour) induces approximately 1.62%, 5.51%, and 5.47% apoptosis, while the percentages of cell necrosis are 2.38%, 8.62%, and 22.50%, respectively.[1]. |
| In vivo | Compared to mice in group D receiving only saline lavage, a single intraperitoneal injection of Chlorhexidine gluconate (0.05%, 0.025%) significantly reduces the incidence of intra-abdominal abscess formation after lavage surgery. There is no significant difference in the incidence of gross adhesions between groups of mice that have or have not undergone surgery[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 30 mg/mL (33.42 mM), Sonication is recommended.
H2O : 80 mg/mL (89.11 mM), Sonication is recommended.
|
| Keywords | Chlorhexidine digluconate |
| Inhibitors Related | Neomycin sulfate | Stavudine | Ampicillin sodium | Kanamycin sulfate | Sodium 4-phenylbutyrate | L-Ascorbic acid | Sulfamethoxazole sodium | Doxycycline | Tributyrin | EDTA copper(II) disodium salt | Salicylic acid | Oleic acid |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max |
United States
