| Name | Cepharanthine |
| Description | Cepharanthine (NSC-623442) is a natural alkaloid that inhibits TNF-α-mediated NFκB stimulation, plasma membrane lipid peroxidation, and platelet aggregation, as well as cytokine production. Cepharanthine exhibits anti-inflammatory, antioxidant, and antitumor activities. |
| In vitro | In a xenograft model using SAOS2 cells in athymic mice, daily treatment with Cepharanthine (20 mg/kg) significantly reduced tumor volume and weight. |
| In vivo | In SaOS2 cells, Cepharanthine (2.5–20 μmol/L) inhibits cell growth in a concentration- and time-dependent manner. At concentrations of 5–10 μmol/L, Cepharanthine markedly suppresses the expression of STAT3 target genes, including the anti-apoptotic gene Bcl-xL and cell cycle regulators c-Myc and cyclin D1. At 10 μmol/L, Cepharanthine induces a cell cycle arrest at the G1 phase and promotes apoptosis in SaOS2 cells. Furthermore, Cepharanthine (10–15 μmol/L) significantly reduces STAT3 expression in SAOS2 cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 9.3 mg/mL (15.33 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 50 mg/mL (82.41 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | proliferation | Inhibitor | Stephania?cephalantha?Hayata | inhibit | NSC 623442 | SARS coronavirus | SARS-CoV | natural product | effective | Cepharanthine | NSC623442 |
| Inhibitors Related | Stavudine | Emtricitabine | Hydroxychloroquine | Guanidine hydrochloride | Lamivudine | Tributyrin | Paeonol | Naringin |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
United States
