Cefoperazone sodium, a third generation cephalosporin, has good antibacterial effect on Enterobacteriaceae and Pseudomonas aeruginosa such as Escherichia coli, Klebsiella spp, Proteus spp, Salmonella typhi, Shigella spp, Citrobacter spp, etc. It has poor effect on Enterobacter aerogenes, Enterobacter cloacae, S. typhimurium and Fusobacterium spp. Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis are highly sensitive to this product. It also has good effect on all groups of streptococci and pneumococci, and only moderate effect on staphylococci (methicillin-sensitive strains), and enterococci are resistant. Cefoperazone has good effect on most gram-positive anaerobic bacteria and some gram-negative anaerobic bacteria, and Bacteroides fragilis is resistant to this product. In inflammation of the meninges, it can enter the cerebrospinal fluid.
Cefoperazone sodium is used for infections of respiratory tract, urinary tract, peritoneum, pleura, skin and soft tissue, bone and joint, five senses, etc. caused by various sensitive bacteria, and also for sepsis and meningitis.
Cefoperazone sodium, a third generation cephalosporin, has good antibacterial effect on Escherichia coli, Klebsiella, Aspergillus, Salmonella typhi, Shigella, Citrobacter and Pseudomonas aeruginosa, and also has good effect on various groups of Streptococcus and Pneumococcus. Cefoperazone has good effect on most gram-positive anaerobic bacteria and some gram-negative anaerobic bacteria.
| Items | Specifications | Results |
| Appearance | White to pale buff crystalline powder | almost white crystalline powder |
| Solubility | Freely soluble in water; soluble in methanol ; slightly soluble in dehydrated alcohol; insoluble in acetone, in ethylacetate, and in ether. | Conform |
| Identification | HPLC | Conform |
| Sodium | Conform |
| Test |
| pH | 4. 5-6. 5 | 5.51 |
| Water | Not more than 5. 0% | 3.3% |
| Crystal Iinity | Meets the requi rements | Conform |
| Bacterial endotoxins | Not more than 0. 20EU/mg | Conform |
| SteriIity | Meets the requi rements | Conform |
| Assay | 870ug ~ 1015ug of cefoperazone
(C25H27N9O8S2) per mg, Calculated on the
anhydrous basis | 950ug/mg |
Application
Cefoperazone sodium is used for infections of respiratory tract, urinary tract, peritoneum, pleura, skin and soft tissue, bone and joint, five senses, etc. caused by various sensitive bacteria, and also for sepsis and meningitis.
Cefoperazone sodium, a third generation cephalosporin, has good antibacterial effect on Escherichia coli, Klebsiella, Aspergillus, Salmonella typhi, Shigella, Citrobacter and Pseudomonas aeruginosa, and also has good effect on various groups of Streptococcus and Pneumococcus. Cefoperazone has good effect on most gram-positive anaerobic bacteria and some gram-negative anaerobic bacteria.
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