Manufacturer Provide Cephadroxil Powder CAS50370-12-2 Cefadroxil Monohydrate
Introduction
Product Name: Cefadroxil Monohydrate
Synonyms: (6R,7R)-7-[(R)-2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-3-METHYL-8-OXO-5-THIA-1-AZA-BICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLIC ACID;CEFAMOX
CAS:50370-12-2
MF: C16H17N3O5S
MW: 363.39
EINECS: 256-555-6
Melting point: 197°C (dec.)
Boiling Point :238°C
Density :1.59
Storage :Keep in dark place,Inert atmosphere,2-8°C
Cefadroxil (Cefadroxil) first generation cephalosporins, has good antibacterial effects on G+ except enterococci bacteria and G- bacteria, such as penicillinase or penicillinase producing strains of Staphylococcus aureus, Staphylococcus epidermidis, pneumococcus, group A hemolytic streptococcus, Escherichia coli, Proteus on this product is sensitive; for Salmonella, Shigella, Haemophilus influenzae, Neisseria gonorrhoeae has antibacterial effect. MRSA, Enterococcus, indole positive Proteus, enterobacter, Sarre and Pseudomonas aeruginosa were resistant to this drug.
Function and Application
Cefadroxil mainly used for urinary tract infection caused by sensitive bacteria, such as urethritis, cystitis, prostatitis, pyelonephritis, gonorrhea; respiratory infections such as pneumonia, sinusitis, bronchitis, pharyngitis, tonsillitis; skin and soft tissue infections, such as Cellulitis, hemorrhoids, otitis media, etc.
| Test Items | Specification | Test Result |
| Appearance | White or almost white,crystalline powder | White crystalline powder |
| Solubility | Sparingly soluble in water, practically insoluble in ethanol(96%) | Conform |
| Identification | IR spectrum should match with that of standard | Conform |
| PH | 4.0~5.5 | 4.8 |
| Water | 4.0%~8.0%, determined on 0.300g | 5.80% |
| Specific Optical Rotation | +149°~+158° ( anhydrous substance ) | +152° |
| Assay | 95.0%~102.0% of C16H17N3O4S | 100.20% |
| ( anhydrous substance) |
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| Related Substances |
| Impurity B | ≤1.0% (compared to the area of the 2nd peak) | <1.0% |
| Any Other Impurity | ≤1.0% (compared to the area of the 1st peak) | <1.0% |
| Total impurity | ≤3.0% | <3.0% |
| Sulphated Ash | ≤0.2%, determined on 1.0g | <0.1% |
| N, N-Dimethylaniline | Not more than 20 ppm | Not used in process |
| Appending Item |
| Tapped Density (g/ml) | -- | 0.93g/ml |
| Conclusion : This product complies as per above BP2010 specifications. |
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