| Name | CDDO-dhTFEA |
| Description | CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD). |
| In vivo | CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (5.74 mM), Sonication is recommended.
DMSO : 100 mg/mL (174.00 mM), Sonication is recommended.
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| Keywords | RTA dh-404 | RTA dh404 | RTA dh 404 | Nuclear factor-κB | Nuclear factor-kappaB | Nrf2 | NF-κB | NFκB | NF-kB | NFkB | Keap1-Nrf2 | Inhibitor | inhibit | CDDO-dhTFEA | CDDOdhTFEA | CDDO dhTFEA |
| Inhibitors Related | TBHQ | Dimethyl fumarate | Lidocaine | Diethylmaleate | Resveratrol | Curcumin | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Ferroptosis Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Antioxidant Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Cancer Active Compound Library | Transcription Factor-Targeted Compound Library |
United States
