| Name | Calcipotriol |
| Description | Calcipotriol (MC 903) is a synthetic vitamin D3 analogue with high affinity for the vitamin D receptor. |
| In vitro | METHODS: HaCaT cells were treated with Calcipotriol (10⁻9 M, 10⁻⁷ M, and 10⁻⁵ M), and Western Blot was used to detect the expression levels of target proteins.
RESULTS: IFN-γinduced K17 protein expression in HaCaT cells, and Calcipotriol dose-dependently inhibited this expression. 10⁻⁷ M and 10⁻⁵ M Calcipotriol inhibited K17 protein expression by 58.10% and 70.68%, respectively. [1]
METHODS: AsPC-1 cells were treated with 100 nM Calcipotriol, and Western Blot was used to detect the expression levels of target proteins.
RESULTS: LRP6 protein levels were significantly decreased after Calcipotriol treatment. [2] |
| In vivo | METHODS: To study the antitumor activity of Diclofenac, Calcipotriol and Difluoromethylornithine, Diclofenac (100 μg/week), Calcipotriol (0.166 μg/week), calcipotriol (0.166 μg/week), The Difluoromethylornithine (463.3 μg/week) mixture was applied to the dorsal surface of mice once a day, five days a week for 17 weeks.
RESULTS: Compared with the placebo group, the Diclofenac plus Calcipotriol group and Diclofenac plus DFMO plus Calcipotriol group showed significantly less weight gain. [3] |
| Storage | keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 122.5 mg/mL (296.9 mM), Sonication is recommended.
Ethanol : 50 mg/mL (121.18 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.69 mM), Sonication is recommended.
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| Keywords | Vitamin D receptor | Vitamin D | VD/VDR | MC-903 | MC903 | Inhibitor | inhibit | Calcipotriol |
| Inhibitors Related | MeTC7 | Acenocoumarol | Ercalcidiol | Retinyl acetate | DL-Panthenol | Maxacalcitol | Ercalcitriol | 5,6-trans-Vitamin D3 | Biotin | Calcipotriol monohydrate | Coumetarol | 24, 25-Dihydroxy VD2 |
United States
