| Name | C75 |
| Description | C75 is an inhibitor synthetic fatty-acid synthase (FASN) and inhibits prostate cancer cells PC3 (IC50: 35 μM).C75 increases CPT1 activity and reduces DIO. |
| In vitro | C75 (10-50 μM) reduces the growth of LNCaP spheroids in a concentration-dependent manner (IC50: 50 μM). (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and produces anorexia. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity [2]. |
| In vivo | C75 (i.p.) blocks fasting-induced c-Fos expression in the arcuate nucleus, lateral hypothalamic area, and paraventricular nucleus. C75 (30 mg/kg, i.p.) inhibits the food intake of mice by ≥95% within 2 h[3]. C75-treated DIO mice have a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA [4]. |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 0.5% CMC-Na : 5 mg/mL (19.66 mM), Suspension.
DMSO : 75.6 mg/mL (297.26 mM), Sonication is recommended.
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| Keywords | PC3 cell | FattyAcidSynthase | Fatty Acid Synthase (FASN) | Fatty Acid Synthase | C75 | C 75 |
| Inhibitors Related | 2-Octanone | Betulin | Denifanstat | Maltitol | Coenzyme A | Pyrazinamide | A-769662 | Orlistat | trans-Chalcone | L-Carnitine | Pseudoprotodioscin | Lycorine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Anti-Viral Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Infection Compound Library | Anti-Cancer Active Compound Library |
United States
