| Name | Buspirone hydrochloride |
| Description | Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). |
| In vitro | Buspirone, a clinically effective non-benzodiazepine anxiolytic drug, causes inhibition of firing of these neurons when given by intravenous (ED50 = 0.011 mg/kg, i.v.), intraperitoneal (ED50 = 0.088 mg/kg, i.p.), and intragastric (effective dose = 1.0-20.0 mg/kg, i.g.) injection. Buspirone also inhibits these cells when it is administered to the outside of recorded neurons by microiontophoresis. [1] Buspirone is eliminated primarily by oxidative metabolism, which produces several hydroxylated metabolites, including 5-hydroxy-buspirone and 1-pyrimidinylpiperazine. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 42.2 mg/mL (100.01 mM), Sonication is recommended.
DMSO : 61.88 mg/mL (146.65 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.74 mM), Sonication is recommended.
|
| Keywords | Serotonin Receptor | Reactive Oxygen Species | Inhibitor | inhibit | DopamineReceptor | Dopamine Receptor | Dopamine | depression | Buspirone Hydrochloride | Buspirone hydrochloride | Buspirone | anxiety | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT1A receptor | 5-HT Receptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | 1,8-Cineole | Ethyl linoleate | Inosine | L-Cystine | Copper Sulfate Pentahydrate | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Dimethyl phthalate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
