Basic information Description Uses Biological Activity Synthesis Overdosage Safety Related Supplier

ChemicalBook Product Catalog API Circulatory system drugs Angina Pectoris Drugs Buflomedil hydrochloride

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Buflomedil hydrochloride NEW

$35.00 100mg

$54.00 500mg

Min. Order
Purity99.7%
Cas No35543-24-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

1YR

United States

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Chemical Properties

Product Name	Buflomedil hydrochloride
CAS No	35543-24-9
EC-No
Min. Order
Purity	99.7%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Buflomedil hydrochloride
Description	Buflomedil hydrochloride (Fonzylane), a vasodilator, is used in therapy of claudication or the symptoms of the peripheral arterial disease.
In vitro	Buflomedil enhances intracellular cAMP levels in human keratinocytes, either secondary to adenyl-cyclase stimulation (BC) or phosphodiesterase inhibition (PTX). Buflomedil diminishes release of TPA-induced TNF-alpha and IL-8 in keratinocytes; in the case of IL-8, this inhibition may occur to transcriptional level. At the micromolar level, Buflomedil notably inhibits epinephrine-induced aggregation. Buflomedil leads to a weak inhibition of collagen- and ADP-induced aggregation. Buflomedil inhibits grainy secretion and the interaction of fibrinogen with its receptor on platelet. the capillary perfusion is improved by Buflomedil hypochloride in such related situations, evoking a possible effect upon neutrophils. Buflomedil Completely inhibits adhesion of histamine related neutrophil (flow system) and partially inhibits adhesion after IL-1-4 hours (flow and stable systems). Buflomedil lowers the hypoxia-induced neutrophil adhesion and expression of P-selectin at the surface of endothelial cells.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	Ethanol : 7 mg/mL (20.35 mM) H2O : 63 mg/mL (183.2 mM) DMSO : 50 mg/mL (145.41 mM)
Keywords	Buflomedil \| inhibit \| Buflomedil hydrochloride \| Inhibitor \| Buflomedil Hydrochloride
Inhibitors Related	Olanzapine \| Mirtazapine \| Octopamine hydrochloride \| Gemfibrozil \| Dexmedetomidine hydrochloride \| Phenylephrine hydrochloride \| Isoprenaline hydrochloride \| Amitriptyline hydrochloride \| Trazodone hydrochloride \| Mianserin hydrochloride
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Obesity Compound Library \| Neurotransmitter Receptor Compound Library \| Drug Repurposing Compound Library \| Anti-Cancer Approved Drug Library \| Bioactive Compounds Library Max \| GPCR Compound Library \| Anti-Cancer Drug Library

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