Name | BSH-IN-1 |
Description | BSH-IN-1 is a potent, covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM for B. longum BSH and 427 nM for B. theta BSH). |
In vitro | BSH-IN-1 also inhibits BSH activity in growing cultures of Gram-negative (Bacteroides fragilis ATCC 25285, B. theta VPI-5482, and Bacteroides vulgatus ATCC 8482) and Gram-positive (C. perfringens ATCC 13124, Lactobacillus plantarum WCFS1, and Bifidobacterium adolescentis L2–32) bacteria. BSH-IN-1 also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis and B. theta, respectively. |
In vivo | In C57BL/6 mice, BSH-IN-1 (10 mg/kg; a single dose; gavage)inhibits BSH activity and can be gut-restricted. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 40 mg/mL (97.9 mM), Sonication is recommended.
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Keywords | BSH IN 1 | BSHIN1 | BSH-IN-1 |
Inhibitors Related | Minoxidil sulfate | Quinine sulfate dihydrate | Quinine | Hydrochlorothiazide | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |