Boronophenylalanine B-10

Product Name:    Boronophenylalanine B-10

Synonyms:    10BenrichedL-4-boronophenylalanine,GMPBPA;Borofalan (10B);L-Phenylalanine,4-(borono-10B);L-4-[10B]Boronophenylalanine;Boronophenylalanine B-10;Acetylcysteine Impurity 35;Borofalan;L-4-Boronophenylalanine

CAS:    80994-59-8

MF:    C9H12BNO4

MW:    208.21

form     Solid

color     White to off-white

Description    Boronophenylalanine B-10 is a boronophenylalanine and boron (boron-10) carrier for boron neutron capture therapy (BNCT) with potential anti-tumour activity. Upon administration, boron flange (10B) is mainly taken up by tumour cells. When irradiated with neutrons, boron flange (10B) absorbs neutrons and self-destructs, releasing short-range alpha radiation and "recoil" lithium in the tumour cells, leading to alpha radiation-induced tumour cell death. This highly selective local radio-targeting of tumour cells spares adjacent normal tissue.