Name | BIO-1211 |
Description | BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM). |
In vitro | BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2]. |
In vivo | In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1]. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 250 mg/mL (352.71 mM)
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Keywords | inhibit | Integrin | BIO1211 | BIO-1211 | BIO 1211 | Inhibitor |
Inhibitors Related | K34c hydrochloride | E7820 | Tirofiban hydrochloride monohydrate | Lifitegrast | Elarofiban TFA | Cyclo(-RGDfK) | Bestatin hydrochloride | RO0270608 | ICAM-1-IN-1 | Gantofiban |
Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Peptide Compound Library | Inhibitor Library | Orally Active Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library |