1. Materials information
Names
| Name |
2-[4-[2-[4-[1-(2-ethoxyethyl)benzimidazol-2-yl]piperidin-1-yl]ethyl]phenyl]-2-methylpropanoic acid
|
| Synonym |
More Synonyms
|
bilastine Biological Activity
| Description |
Bilastine is a selective histamine H1 receptor antagonist used for
treatment of allergic rhinoconjunctivitis and urticaria. Target:
Histamine H1 ReceptorBilastine binds to histamine H1-receptors as
indicated by its displacement of [3H]-pyrilamine from H1-receptors
expressed in guinea-pig cerebellum and human embryonic kidney (HEK) cell
lines. The studies conducted on guinea-pig smooth muscle demonstrated
the capability of bilastine to antagonise H1-receptors. Bilastine is
selective for histamine H1-receptors as shown in receptor-binding
screening conducted to determine the binding capacity of bilastine to 30
different receptors [1]. Bilastine distribution has an apparent volume
of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h
and plasma protein binding of 84-90% [2]. |
| Related Catalog |
Signaling Pathways >>
GPCR/G Protein >>
Histamine Receptor
Signaling Pathways >>
Immunology/Inflammation >>
Histamine Receptor
Research Areas >>
Inflammation/Immunology
|
| References |
[1]. Corcostegui,
R., et al., Preclinical pharmacology of bilastine, a new selective
histamine H1 receptor antagonist: receptor selectivity and in vitro
antihistaminic activity. Drugs R D, 2005. 6(6): p. 371-84. [2]. Jauregizar,
N., et al., Pharmacokinetic-pharmacodynamic modelling of the
antihistaminic (H1) effect of bilastine. Clin Pharmacokinet, 2009.
48(8): p. 543-54.
|
Chemical & Physical Properties
| Density |
1.2±0.1 g/cm3 |
| Boiling Point |
639.1±55.0 °C at 760 mmHg |
| Melting Point |
202 °C |
| Molecular Formula |
C28H37N3O3 |
| Molecular Weight |
463.612 |
| Flash Point |
340.3±31.5 °C |
| Exact Mass |
463.283478 |
| PSA |
67.59000 |
| LogP |
5.06 |
| Vapour Pressure |
0.0±2.0 mmHg at 25°C |
| Index of Refraction |
1.594 |
2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
4. Contact information
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