Name | beta-Amyrone |
Description | beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM. beta-Amyrone has anti-inflammatory activity through inhibiting the expression of COX-2. beta-Amyrone exhibits anti-α-glucosidase inhibitory activity and moderate AChE activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity. |
In vitro | beta-Amyrone inhibits α-glucosidase AChE and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[1]. In LPS-stimulated J774 cells, beta-Amyrone (2.5, 5, 10 μg/mL) inhibits NO production with an IC50 value of 4.61 μg/mL without obvious effects on cell viability[4]. beta-Amyrone (10 μg/mL) inhibits IL-6, IL-10 levels, and COX-2 expression at the dose of 10 μg/mL[4]. |
In vivo | In ear phenol-induced edema in Balb C mice, beta-Amyrone (0.1, 0.3, 0.6 mg/kg) inhibits ear edema formation in a dose-related manner[4]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : Insoluble
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Keywords | antifungal | AChE | COX-2 | PI3K-Akt | Anti-inflammatory | Fungal | inflammation | beta-Amyron | β-Amyrone | CHIKV | Cyclooxygenase | b-Amyron | inhibit | Inhibitor | infection | beta-Amyrone | obesity | Peroxisome proliferator-activated receptors | COX | b-Amyrone | PPAR |
Inhibitors Related | Bismuth Subsalicylate | Ibuprofen | Acetaminophen | Daidzein | Metronidazole | L-Lysine | Diclofenac sodium | Diclofenac Potassium | Naringenin | Paradol | Salicylic acid | 2,3-Butanediol |
Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library |