contact details:
Wickr Me: godbullrawalisa
Whatsapp/ Skype/ WeChat: 8618986288449
Email: Alisasales@godbullraw.com
product name: SR9011
CAS 1379686-29-9
purity:99%
appearance: white powder
1. SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates.
2. Recommended for use in peroxide cured coatings, sealants, and PCV-based plastisols. Performance properties include: good adhesion, good chemical resistance, good hardness, good heat resistance and high abrasion resistance.
SR9011 Biological Activity:
1. SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure.
2. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.
3. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver,
4. skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia.
5. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic
FAQ:
Q1: Do you offer free sample?
A: Of course, we will offer free sample if you pay shipping fees.
Q2: How to solve the quality problem?
A: We supply high quality products and quality issue near to zero. If it happens caused by occasional case, we will reship again or compensate customer loss, but customer need show us the evidence of problems or test report.
Q3: Whether transportation is safe and whether to reship if seized?
A: Yes, we offer almost 100% Shipping line with safe delivery. If seized unfortunately, we will ship and I am sure no custom issue.
Q4: ETA ?
A: Pack sent out in 2-3 days and offer tracking numbers after payment. ETA not the same decide by destination country. Please contact us for details (always 10-15 days).
Q5: Do you have any discount?
A: The price is negotiable. Plz shoot us your order content, we will quote a fair price.
Q6: What is your minimum order ?
A: Usually MOQ is 100g. But depends on the items and your requirements, we also can support small quantity, such as 20g and 50g.
Q7: How to order?
A: E-mail or message us that includes your order like format below:
product A 100g
product B 10vials
delivery country:
Our sales will quote a total cost includes shipping fees and each item fees in 12 hours regularly.
Our will satisfy your purchase and supply professional guide.
China
