The local anesthetic benzocaine hydrochloride is the hydrochloride form of the local anesthetic benzocaine. It has the same pharmacological action as benzocaine and the anesthetic effect is weaker than procaine. Local absorption is slow and the effect is long lasting. Because it is insoluble in water, it can not be used as infiltrating anesthesia, and has analgesic and itchy effects. The drugs are usually made into powder or oil paste, and are used clinically to treat wounds, ulcers, burns, skin abrasions and hemorrhoids. Benzocaine, also known as ethyl p-aminobenzoate, Sinai. It is a colorless or white rhombic crystalline acicular crystal or crystalline powder precipitated from water, and a square crystal precipitated from ether. No smell. It has a bitter taste. Chemicalbook molecular weight 165.19. Melting point 92℃. The boiling point is 310℃, 183 ~ 184℃(1.87×103Pa). Insoluble in water, soluble in ethanol, ether, and chloroform, but also soluble in almond oil, olive oil, and dilute acids. Stable in air. Using p-nitrotoluene as raw material, it is oxidized with sodium dichromate in sulfuric acid to produce p-nitrobenzoic acid, and esterified with ethanol. After the reaction is completed, the ethyl p-nitrobenzoate is separated, and the crude benzocaine can be obtained by reducing it in acetic acid solution with iron powder at 85 ~ 95℃. After separation, it is washed with water and then recrystallized in ethanol for refining.
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