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ChemicalBook Product Catalog BDP5290

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BDP5290 NEW

$51.00 1mg

$74.00 2mg

$122.00 5mg

Min. Order
Purity97.22%
Cas No1817698-21-7
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	BDP5290
CAS No	1817698-21-7
EC-No
Min. Order
Purity	97.22%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	BDP5290
Description	BDP5290 is a potent inhibitor of both ROCK and MRCK, with IC50 values of 5 nM for ROCK1, 50 nM for ROCK2, 10 nM for MRCKα, and 100 nM for MRCKβ.
Cell Research	MDA MB 231 or SCC12 cells were plated in a 96 well plate and cultured for 24 hours.?Cells were then cultured for 24 hours in SCC12 medium with DMSO vehicle, 2 μM Y27632 or indicated concentrations of BDP5290 in an IncuCyte ZOOM.?Pictures were taken every 3 hours and confluence was measured using the IncuCyte analysis software.?AlamarBlue was added to the medium and the cells were cultured for an additional day.?Absorbances at 570 nm and at 600 nm were measured to assess cell health.
In vitro	BDP5290 as a potent MRCK inhibitor.?X-ray crystallography of the MRCKβ kinase domain in complex with BDP5290 revealed how this ligand interacts with the nucleotide binding pocket.?BDP5290 demonstrated marked selectivity for MRCKβ over ROCK1 or ROCK2 for inhibition of myosin II light chain (MLC) phosphorylation in cells.?While BDP5290 was able to block MLC phosphorylation at both cytoplasmic actin stress fibres and peripheral cortical actin bundles, the ROCK selective inhibitor Y27632 primarily reduced MLC phosphorylation on stress fibres.?BDP5290 was also more effective at reducing MDA-MB-231 breast cancer cell invasion through Matrigel than Y27632.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 12.5 mg/mL (33.62 mM)
Keywords	inhibit \| Rho-kinase \| BDP-5290 \| Rho-associated kinase \| BDP5290 \| Rho-associated protein kinase \| ROK \| BDP 5290 \| Inhibitor \| ROCK
Inhibitors Related	SB-747651A Dihydrochloride \| GSK180736A \| SAR407899 hydrochloride \| RKI-1447 \| Belumosudil \| Fasudil hydrochloride \| Y-27632 dihydrochloride \| Tofacitinib \| Y-27632 \| ROCK-IN-5 \| Thiazovivin \| CAY10746
Related Compound Libraries	Neural Regeneration Compound Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Inhibitor Library \| NO PAINS Compound Library \| Stem Cell Differentiation Compound Library \| Bioactive Compounds Library Max \| Cell Cycle Compound Library \| Cytoskeletal Signaling Pathway Compound Library \| TGF-beta/Smad Compound Library

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