| Name | BAY 2416964 |
| Description | BAY 2416964 is a small molecule inhibitor that selectively targets aromatic receptor (AhR) with an IC50 of 341 nM and is commonly used in cancer immunotherapy research. |
| In vitro | METHODS: Human monocytes were treated with BAY 2416964 (1 nM-10 µM), kynurenic acid (200 µM), and LPS (10 ng/mL) for 24 h, and TNF-α levels were measured by ELISA.
RESULTS: kynurenic acid-induced AhR activation inhibited TNF-α production in LPS-stimulated monocytes, and BAY 2416964 dose-dependently rescued this AhR-mediated inhibition. [1] |
| In vivo | METHODS: To assay antitumor activity in vivo, BAY 2416964 (30 mg/kg) was administered orally to NSG mice bearing B16F10-OVA tumors once daily for seven days.
RESULTS: BAY 2416964 inhibited tumor growth.BAY 2416964 increased the frequency of immunostimulatory tumor-infiltrating CD8+ T cells and N cells, and decreased the frequency of immunosuppressive GR1-positive myeloid cells and CD206+M2 macrophages. [1] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (644.63 mM), Sonication is recommended.
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| Keywords | inhibit | Aryl Hydrocarbon Receptor | CYP1A1 | Inhibitor | AhR | anti-cancer | BAY-2416964 | BAY 2416964 | BAY2416964 |
| Inhibitors Related | Carbidopa monohydrate | Diosmin | AHR antagonist 2 | SGA360 | Benzyl butyl phthalate | Skatole | Carbidopa | L-Kynurenine | Indole-3-carbinol | MeBIO | StemRegenin 1 | PD98059 |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | NO PAINS Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
