| Name | Azoramide |
| Description | Azoramide, a small-molecule modulator, has the antidiabetic activity of unfolded protein response. |
| In vitro | Azoramide, a dual-function endoplasmic reticulum (ER) modulator, improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. |
| In vivo | In two independent mouse models of obesity, Azoramide exhibits potent antidiabetic efficacy by improving insulin sensitivity and pancreatic β cell function. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (32.38 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
10% DMSO+40% PEG300+ 5% Tween 80 + 45% Saline : 10 mg/mL (32.38 mM), Solution.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.48 mM), Sonication is recommended.
DMSO : 100 mg/mL (323.8 mM), Sonication is recommended.
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| Keywords | unfolded protein response | PERK | mitochondrial function | Inhibitor | inhibit | ER protein fold | ER chaperone capacity | DA neurons | CERB signaling | Azoramide | Apoptosis | antidiabetic |
| Inhibitors Related | Ethoxyquin | Stavudine | Kaolin | Aceglutamide | Allopurinol | Urea | L-Cysteine | Ethyl linoleate | Formamide | Gluconate Calcium | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Apoptosis Compound Library | NF-κB Signaling Compound Library | Glycometabolism Compound Library | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Kinase Inhibitor Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
United States
