Name | AZD9056 hydrochloride |
Description | AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation. |
In vitro | The antagonist AZD9056 blocks P2X7 receptors with an IC50 of 11.2 nM in the HEK-hP2X7 cell line, indicating high selectivity for the receptor. Additionally, AZD9056 exhibits a clear inhibitory effect (IC50=1-3 μM) in mouse microglia BV2 cells[1]. |
In vivo | Treatment with AZD9056 demonstrates analgesic and anti-inflammatory properties by reversing the MIA-induced upregulation of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP), and prostaglandin E2 (PGE2) in cartilage tissues. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 48 mg/mL (105.39 mM), Sonication is recommended.
|
Keywords | AZD 9056 Hydrochloride | AZD9056 hydrochloride | AZD 9056 | AZD-9056 | AZD9056 Hydrochloride | P2X Receptor | P2XRs | Inhibitor | AZD-9056 Hydrochloride | AZD-9056 hydrochloride | AZD9056 | inhibit |
Inhibitors Related | Opiranserin hydrochloride | Aurintricarboxylic acid | (E/Z)-Sivopixant | PSB-12062 | ATP disodium salt | Oxatomide | JNJ-55308942 | JNJ-42253432 | Ivermectin | Lappaconitine | CTP disodium dihydrate | Brilliant blue G-250 |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |