| 名称 | AUDA |
| 描述 | AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively) |
| 细胞实验 | Cell Line:Vascular smooth muscle cell (VSMC).Concentration:0.3, 1, 3, 10 μg/mL. Incubation Time:48 hours[1] |
| 动物实验 | AUDA (i.p.; 10 mg/kg; 14 days) reduces TNF-α, MMP-9 and IL-1β expression levels.Animal Model:Male (wild-type). C57BL/6 mice (age, 4-6 weeks; weight, 18-20 g).Dosage:10 mg/kg.Administration:i.p.; 14 days[2] |
| 体外活性 | AUDA significantly inhibited PDGF-induced rat VSMC proliferation, which coincided with Pin1 suppression and heme oxygenase-1 (HO-1) upregulation.?However, exogenous 8,9-EET, 11,12-EET, and 14,15-EET treatments did not alter Pin1 or HO-1 levels and had little effect on the proliferation of rat VSMCs.?On the other hand, AUDA enhanced the PDGF-stimulated cell migration of rat VSMCs.?Furthermore, AUDA-induced activation of cyclooxygenase-2 (COX-2) and subsequent thromboxane A2 (TXA?) production were required for the enhanced migration[1]. |
| 体内活性 | AUDA increased the proliferation, migration, adhesion and tube formation ability of HCAECs in a dose-dependent manner.?Furthermore, in the mouse model of KD, AUDA reduced the protein expression of MMP-9, IL-1β and TNF-α, indicating that AUDA may alleviate inflammatory reactions in the coronary arteries of KD model mice[2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 30 mg/ml (76.41 mM)
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| 关键字 | Inhibitor | anti-inflammatory | epoxide | inhibit | AUDA | hydrolase | sEH | activity | soluble | Epoxide Hydrolase | VSMC |
| 相关产品 | 1,3-Diphenylurea | Valpromide | VU534 | N,N'-Dicyclohexylurea | Diflapolin | (Rac)-EC5026 | CAY10640 | sEH inhibitor-3 | GSK2256294A | EC5026 | Dual FAAH/sEH-IN-1 | CUDA |
| 相关库 | 细胞凋亡化合物库 | 经典已知活性库 | 神经退行性疾病化合物库 | 抗阿尔茨海默症化合物库 | 抑制剂库 | NO PAINS 化合物库 | 代谢化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 活性脂质化合物库 |
United States
