| 名称 | Aucuparin |
| 描述 | Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging activity. Aucuparin inhibited superoxide production of human neutrophils induced by fmlp, and its IC50 was 17.0μM. |
| 体外活性 | The formation of Aucuparin, a well-known biphenyl, is induced by yeast extract (YE) in cell cultures of Sorbus aucuparia. Here we demonstrate that the addition of YE to the cell cultures results in a burst of reactive oxygen species (ROS; H(2)O(2) and O(2) (-)), followed by transcriptional activation of the biphenyl synthase 1 gene (BIS1) encoding the key enzyme of the biphenyl biosynthetic pathway and Aucuparin accumulation.
When the cell cultures were pretreated with superoxide dismutase specific inhibitor N,N-diethyldithiocarbamic acid, although O(2) (-) continued to be generated, the H(2)O(2) accumulation, BIS1 expression, and Aucuparin production were blocked. Interestingly, an exogenous supply of H(2)O(2) in the range of 0.05-10 mM failed to induce Aucuparin accumulation. These results indicate that endogenous generation of H(2)O(2) rather than that of O(2) (-) is a key factor in YE-induced accumulation of biphenyl phytoalexins in cell cultures of S. aucuparia.[1] |
| 体内活性 | Aucuparin, a natural product isolated from Sorbus aucuparia, inhibited pulmonary fibrosis in bleomycin (BLM)-induced lung fibrosis mouse model. In the lung samples of mice treated with aucuparin, the gene expression of inflammation and macrophage activation markers was reduced compared to those treated with BLM alone. Moreover, aucuparin decreased the expression of profibrotic marker genes and increased the expression of antifibrotic marker genes. Finally, we observed that aucuparin significantly suppressed transforming growth factor-β-induced activation of inflammatory cytokine production and collagen synthesis from macrophages and fibroblasts, respectively. [3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 2.3 mg/mL (13.2 mM)
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| 关键字 | Aucuparin |
| 相关产品 | Ketoconazole | ML-090 | APX-115 | Setanaxib |
| 相关库 | 经典已知活性库 | 中药单体化合物库 | 植物来源化合物库 | 中药抗炎分子库 | 高通量筛选天然产物库 | 抗感染天然产物库 | 抗衰老化合物库 | 已知活性化合物库 |
United States
