Name | Atpenin A5 |
Description | Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1]. |
In vitro | Atpenin A5 effectively inhibits submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, exhibiting IC50 values of 8.3 nM, 9.3 nM, and 8.5 nM, respectively. It acts as a potent, specific inhibitor of complex II. Moreover, at a concentration of 1 nM, Atpenin A5 (AA5) activates the mitochondrial ATP-sensitive potassium (mKATP) channel and offers protection against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1]. |
In vivo | Atpenin A5, a potent succinate dehydrogenase (SDH) inhibitor, promotes cardiomyocyte mitosis and regeneration in the postnatal heart following myocardial infarction (MI). Mice injected with Atpenin A5 (100 μg/kg) showed increased myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2]. |
Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 100 mg/mL (273.04 mM), Sonication is recommended.
|
Keywords | Atpenin A5 | preconditioning | sensitive | mKATP | Atpenin A 5 | ischemia | potassium | complex II | Inhibitor | cardioprotective | channel | mitochondrial | Potassium Channel | KcsA | ATP | inhibit | reperfusion | Atpenin A-5 |
Inhibitors Related | Minoxidil sulfate | Halothane | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Neuroprotective Compound Library | Microbial Natural Product Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |