| Name | Atipamezole hydrochloride |
| Description | Atipamezole is a synthetic α2 adrenergic receptor antagonist. It has also been researched in humans as a potential anti-Parkinsonian drug. Atipamezole hydrochloride (MPV-1248 hydrochloride) is hydrochloride form of atipamezole. |
| In vitro | The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1]. |
| In vivo | Atipamezole has been found to be well tolerated in rodents and displays only modest cardiovascular effects at dosages ranging from 0.01–1 mg/kg, administered intravenously, in anesthetized, normotensive rats. This compound is frequently utilized by veterinarians to reverse sedation or anesthesia in animals. Additionally, it has been observed to enhance sexual activity in both rats and monkeys. In situations of sustained nociception, atipamezole augments pain-related responses by inhibiting the noradrenergic feedback mechanism that normally suppresses pain. Furthermore, at low doses, atipamezole positively affects several cognitive functions in experimental animals, including alertness, selective attention, planning, learning, and recall, though its impact on short-term working memory remains unclear. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 16.67 mg/mL (67 mM), Sonication is recommended.
H2O : 24.9 mg/mL (100 mM)
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| Keywords | Atipamezole Hydrochloride | MPV1248 Hydrochloride | MPV 1248 Hydrochloride | Atipamezole hydrochloride | Beta Receptor | Adrenergic Receptor | MPV 1248 | Inhibitor | MPV-1248 Hydrochloride | MPV1248 | Atipamezole | inhibit | MPV-1248 |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Isoprenaline hydrochloride | Amitriptyline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Neurotransmitter Receptor Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
