| 名称 | AT-533 |
| 描述 | AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α/VEGF/VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1/2, FAK, Akt/mTOR/p70S6K,. AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs). |
| 体外活性 | AT-533 (0-1350 nM; 24h or 48h) inhibits 20 ng/mL VEGF-induced tube formation, cell migration, and HUVEC invasion. Additionally, AT-533 (2 μM or 75 μM; 24h) hinders the HIF-1α/VEGF signaling pathway in hypoxia-induced breast cancer cells and inhibits Akt/mTOR/p70S6K, Erk1/2, and FAK phosphorylation. It shows anti-angiogenic activity on the chorionic villus (CAM) model at 10 nM and 50 nM over 48h. Furthermore, AT-533 (0.5 μM; 2 or 4 hours) reduces TNF-α, IL-1β, and IL-6 production induced by HSV-1 in RAW264.7 and BV2 cells [1, 2]. |
| 体内活性 | AT-533 (10 mg/kg; intraperitoneal injection; once daily for 21 days) inhibited the expression of HIF-1α/VEGF signaling pathway-related proteins in a mouse MDA-MB-231 xenograft model of breast cancer [1]. AT-533 (1, 2, 4 mg/kg; intraperitoneal injection; once daily for 30 days) did not cause death, appetite loss, weight loss, or adverse reactions in subacute toxicity tests of Sprague Dawley rats [3]. |
| 存储条件 | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (146.16 mM), Sonication is recommended.
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| 关键字 | AT 533 | AT533 | Benzamide,2[(trans4hydroxycyclohexyl)amino]4(4,5,6,7tetrahydro3,6,6trimethyl4oxo1Hindazol1yl) | AT-533 |
| 相关产品 | Floxuridine | Docusate sodium | Octyl gallate | 1-Docosanol | Oxytetracycline Hydrochloride | 2-Deoxy-D-glucose | S-Methylisothiourea sulfate | Oxyresveratrol | Idoxuridine | Acyclovir | Palmitic acid | Ganciclovir |
| 相关库 | 外泌体相关化合物库 | 经典已知活性库 | 抗病毒库 | 抑制剂库 | 已知活性化合物库 | 细胞骨架化合物库 | 抗癌活性化合物库 |
United States
