| Name | Anticancer agent 73 |
| Description | Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells. |
| In vitro | Anticancer agent 73 (compound CIB-3b) (10 μM; 6 h) elevates E-cadherin expression and reduces fibronectin, N-cadherin, and vimentin protein levels in SK-HEP-1 cells. It also inhibits the proliferation and migration of SK-HEP-1, HCCLM3, and MHCC97L cells by impeding miRNA biogenesis.[1] |
| In vivo | Anticancer agent 73 (compound CIB-3b) (10, 25, and 50 mg/kg; i.v.; every 2 days for 4 weeks; SCID mice) diminishes the proliferation and migration of both SK-HEP-1 cells and SK-HEP-1 cells implanted in SCID mice.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.63 mM), Sonication is recommended. DMSO : 90.0 mg/mL (344.5 mM), Sonication is recommended.
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| Keywords | TRBP | RNASynthesis | RNA Synthesis | DNASynthesis | DNA Synthesis |
| Inhibitors Related | 5-Fluorouracil | Procaine | Rifaximin | Capecitabine | Ribavirin | Guanidine hydrochloride | Methotrexate disodium | Cytarabine | Acyclovir | Thymidine | Temozolomide | Folic acid |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |