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ChemicalBook Product Catalog Ansofaxine hydrochloride

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Ansofaxine hydrochloride NEW

$71.00 1mg

$172.00 5mg

$278.00 10mg

Min. Order
Purity99.77%
Cas No916918-84-8
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Ansofaxine hydrochloride
CAS No	916918-84-8
EC-No
Min. Order
Purity	99.77%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Ansofaxine hydrochloride
Description	Ansofaxine hydrochloride (LY03005) is a serotonin-norepinephrine-dopamine reuptake inhibitor (IC50s: 723, 763 and 491 nM, respectively).
Animal Research	The dosages of LPM570065 and desvenlafaxine used with different administration routes referred to previous studies and was determined by preliminary experiments. Oral solutions of LPM570065 and desvenlafaxine for intragastric administration (0.06 mmol/kg p.o.) were prepared by dissolving the compounds in 10% glucose. Oral suspensions of LPM570065 and desvenlafaxine for intragastric administration (0.06 mmol/kg p.o.) were prepared by suspending the compounds in 0.5% carboxymethylcellulose sodium. Intravenous solutions of LPM570065 and desvenlafaxine for intravenous administration (0.04 mmol/kg i.v.) were prepared by dissolving the compounds in 10% glucose. WAY-100635 was dissolved in 0.9% saline and was administered subcutaneously (0.3 mg/kg s.c.). Raclopride was dissolved in 0.9% saline and was administered subcutaneously (0.5 mg/kg s.c.). Different vehicles were used for administration using different administration routes [1].
In vivo	Acute administration was performed by providing rodents with oral solutions (0.06 mmol/kg p.o.), oral suspensions (0.06 mmol/kg p.o.) and intravenous solutions (0.04 mmol/kg i.v.) of Ansofaxine and desvenlafaxine. Oral suspensions (0.06 mmol/kg/day) of the two drugs were also administered for a 14-day chronic period. Ansofaxine rapidly penetrated the rat striatum, converted into desvenlafaxine and exhibited larger total exposure compared with the administration of desvenlafaxine. Acute and chronic administration of oral suspension of Ansofaxine increased the 5-HT, DA and NE levels more than the relative administration of desvenlafaxine [1]. The maximum tolerated dose (MTD) was 500mg/kg and the lethal dose was 1000mg/kg in SD rats after a single administration of Ansofaxine. In 13-week repeated-dose oral toxicity, the no-observed-adverse-effect level (NOAEL) of Ansofaxine was greater than 300mg/kg for rats [2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 16.67 mg/mL (39.88 mM)
Keywords	5-hydroxytryptamine Receptor \| Dopamine Receptor \| Ansofaxine hydrochloride \| inhibit \| Ansofaxine Hydrochloride \| Serotonin Receptor \| LY 03005 \| Ansofaxine \| LPM 570065 \| Inhibitor \| LPM-570065 \| 5-HT Receptor \| LY-03005
Inhibitors Related	Alverine citrate \| Dapoxetine hydrochloride \| Octopamine hydrochloride \| Oxolinic acid
Related Compound Libraries	Anti-Neurodegenerative Disease Compound Library \| Bioactive Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| GPCR Compound Library

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